What’s the Difference between Progesterone Gel (Crinone), Progesterone Insert (Endometrin), and Progesterone in Oil?

Progesterone

Before starting a new fertility plan, you may have questions about your prescribed medication, its side effects, or whether one type of medication is more effective than another. At Mandell’s Clinical Pharmacy, our mission is to support every patient through ongoing education and access to the medications and services they need to achieve their goals of becoming pregnant.

One question we often receive from patients is why their doctors would prescribe progesterone gel over progesterone insert or progesterone in oil and vice versa.

Before we dive into this topic, let’s first define what progesterone is and how it works.

What Is Progesterone?

Progesterone is the female hormone responsible for regulating the menstrual cycle and preparing the uterus for pregnancy. If you have a history of progesterone deficiency, it may be more difficult for you to become pregnant or you may be at higher risk for miscarriages.

Why Is Progesterone Used?

If you are experiencing progesterone deficiency, your doctor may prescribe a progesterone replacement to help maintain the lining of the uterus so that the embryo will implant and sustain a healthy pregnancy.

How Is Progesterone Administered?

Progesterone may be administered in one of three ways:

  • Progesterone Gel (Crinone): Crinone Gel functions as a progesterone replacement for women with luteal phase defect. Women undergoing an Assisted Reproductive

Technology (ART) program may be prescribed Crinone gel to support their IVF journey to

successful embryo implantation and the maintenance of pregnancy.

  • Progesterone Insert (Endometrin): Unlike progesterone in its gel form, Endometrin is administered via a small tablet inserted into the vagina. The tablet comes

with disposable applicators to ensure proper placement near the vaginal tissue, where it can be easily dissolved.

  • Progesterone in Oil: This type of intramuscular (IM) injection is used to help thicken your uterine lining to protect the embryo and secure its healthy growth and development.

Whether one method of progesterone is more effective than the other will depend on several factors, including your health history, production of progesterone, and your IVF treatment plan.

Understanding Progesterone Delivery Methods:

Which One Is Right for You?

Whichever delivery method is best for you, Mandell’s Clinical Pharmacy can fill your prescription and provide you with the education and support you need to feel confident about your fertility journey.

If you have questions about current medication or want to learn more about your progesterone options, contact us today or visit our pharmacy location for an in-person consultation. We offer a wide variety of services, including home delivery, 24/7 emergency access and support, discount programs, and financing.

You’re not alone in your fertility journey. Let us help you along the way and provide you with the support and state-of-the-art national fertility pharmacy you deserve!