Crinone (progesterone gel)

Crinone Progesterone Gel is a supplement used to replace progesterone—the female hormone responsible for regulating the menstrual cycle and preparing the uterus for pregnancy. Women who experience progesterone deficiency may have difficulty getting pregnant or be at a higher risk for miscarriages, as high progesterone levels are essential to maintaining a healthy pregnancy.

FDA approved, Crinone Gel functions as a progesterone replacement for women with luteal phase defect. This condition affects the production of progesterone in the ovaries during the second half of women’s menstrual cycles. For women undergoing an Assisted Reproductive Technology (ART) program, Crinone may be prescribed to support you on your IVF journey to successful embryo implantation and the maintenance of pregnancy.

Fill Your Prescription at Mandell’s Clinical Pharmacy

Crinone Progesterone Gel Instructions & Video Tutorial

To help you successfully administer your first intravaginal progesterone gel at home, watch our video tutorial for step-by-step instructions.

The single-use, one-piece polyethylene applicator is designed with your comfort in mind to ensure proper vaginal administration of the progesterone vaginal gel.

How to store Crinone Progesterone Gel:

Store at room temperature between 59°F and 77°F (15°C and 25°C). Protect gel from sunlight.

Crinone Progesterone Gel Side Effects:

Every individual will respond to this medication differently.

Common side effects may include:

  • Breakthrough Bleeding
  • Weight Changes
  • Acne
  • Skin Sensitivity Reactions
  • Hair Loss
  • Changes in Cervical Secretions
  • Breast Tenderness
  • Secretion of Breast Milk
  • Nausea
  • Dizziness
  • Fever
  • Insomnia
  • Fluid Retention
  • Depression

Contact your physician immediately if you experience any of the following:

  • Numbness or Pain in the Arm or Leg
  • Pain in the Chest or Groin
  • Breast Tenderness or Enlargement
  • Severe Headache
  • Stomach Pain
  • Unusual Weakness
  • Vision or Speech Problems
  • Yellowing of the Skin
  • Sudden Shortness of Breath

What if I Miss a Crinone Progesterone Gel Dosage?

If you miss a dosage on the same day, you may usually administer the dose as soon as you remember; however, contact your physician during office hours to let them know. Do not double the dose on your own.

Always speak to your physician before continuing your doses.

Questions About Crinone Progesterone Gel for Fertility?

While embarking on a new fertility journey, it’s essential that you feel supported throughout your journey. At Mandell’s Clinical Pharmacy, we offer the services, education, and personalized guidance you deserve to feel comfortable and confident about your treatment plan. 

For more information on injecting Crinone Progesterone Gel at home, or if you have questions about other fertility medications, contact our pharmacy today. We’re available and here for you!