Endometrin (progesterone insert)

ENDOMETRIN® (progesterone) is a vaginal insert that contains the female hormone progesterone, which is responsible for maintaining the lining of the uterus so that the embryo will implant and sustain a healthy pregnancy.

As part of your Assisted Reproductive Technology (ART) program, your clinician may prescribe ENDOMETRIN to help you produce higher levels of progesterone to prepare your uterus for pregnancy.

ENDOMETRIN Tablet vs. Crinone Progesterone Gel

ENDOMETRIN differs from the progesterone replacement medication Crinone, as it delivers the medication via a small tablet inserted into the vagina, rather than in gel form. The tablet comes with disposable applicators to ensure proper placement near the vaginal tissue, where it can be easily dissolved.

Fill Your Prescription at Mandell's Clinical Pharmacy

How Do You Insert Endometrin Vaginal Tablet?

ENDOMETRIN Progesterone tablet is inserted into the vagina with an applicator. To help you successfully insert your first ENDOMETRIN Vaginal tablet at home, download the following instructions.

Download Complete Usage Instructions

NOTE: As noted in the instructions, use ENDOMETRIN exactly as prescribed. Use the disposable applicator provided. Do not use other vaginal products while using this medication.

For questions about exact dosage and frequency, contact your clinician.

How to Store the ENDOMETRIN Progesterone Insert

ENDOMETRIN may be stored at room temperature. For questions about storing and handling or if you have questions about your medication's expiration date, contact our pharmacy today!

ENDOMETRIN Progesterone Side Effects

Depending on your individual treatment plan and health history, you may respond to this medication differently. Common side effects seen with ART and ENDOMETRIN include:

  • Pelvic Pain after Surgery
  • Abdominal Pain
  • Nausea
  • Swollen Ovaries (ovarian hyperstimulation syndrome)

NOTE: Progesterone can increase your chances of developing blood clots, which can cause serious complications.

Call your doctor and get medical help right away if you experience any of the following symptoms:

  • Persistent Lower Leg Pain
  • Sudden Shortness of Breath
  • Coughing up Blood
  • Sudden Blindness (partial or complete)
  • Severe Chest Pain
  • Sudden Severe Headache
  • Vomiting
  • Dizziness or Fainting
  • Weakness in the Arm or Leg
  • Trouble Speaking
  • Yellowing of the Skin and/or White of the Eyes (indicating possible liver problems)

What if I Miss an ENDOMETRIN Dosage?

If you miss a dosage on the same day, you may usually insert the dose as soon as you remember; however, contact your physician for further instructions. Do not double the dose on your own.

Speak to your physician before administering your next dosage.

Questions About ENDOMETRIN Progesterone?

Get all the facts and information you need to feel confident about your fertility treatment plan. Trust our team at Mandell’s Clinical Pharmacy to answer your questions and provide you with the ongoing support, guidance, and education you need to be successful and stay informed.

For more information on how to insert ENDOMETRIN, or for questions about other progesterone replacement options, contact our pharmacy today.

We look forward to being here for you!

Return to Medication Instructions