Pregnyl (human chorionic gonadotropin for injection)

Pregnyl® is an injectable human chorionic gonadotropin (HCG) hormone commonly used in fertility treatment.

HCG is a hormone that’s naturally occurring in pregnant women. While its natural purpose differs from that of the injections, HCG reacts the same within the body as the luteinizing hormone (LH), a vital fertility hormone responsible for stimulating follicular development, mature oocyte (i.e. egg) development, and ovulation.

Pregnyl is used in women in combination with gonadotropin injections, to produce mature eggs and trigger ovulation during infertility treatment. 

Other Common HCG Injection Brands:

  • Novarel
  • Ovidrel

How to Inject Pregnyl

Pregnyl injections should only be done under the supervision of a physician. Before self-injecting Pregnyl, be sure to discuss with your physician or another medical professional how to safely and properly self-administer Pregnyl and what your unique dosage, frequency, and treatment duration is. It’s important not to miss a dose of your Pregnyl injections; your injection administration needs to be performed on the exact date and time instructed by your physician. If you miss your scheduled dose, immediately contact your physician for further instructions.

When you’re ready to administer your Pregnyl injection, be sure to have the following items at the ready:

  • Vial of Pregnyl powder
  • Vial Pregnyl solvent
  • Disposable syringe
  • Sterile reconstituting needle
  • Sterile intramuscular injection needle
  • Alcohol wipes or sterile cotton balls with Isopropyl alcohol
  • Gauze
  • Needle disposal storage container

Pregnyl injections are administered below either below the skin (subcutaneously) or in the muscle, as instructed by your physician.   


Store at room temperature between 59°F and 77°F (15°C and 25°C.

Common Side Effects/Comments

Common side effects include abdominal pain, bloating, breast pain, nausea. This drug can also cause Ovarian Hyperstimulation syndrome (OHSS) which should be treated as a serious matter and doctor should be notified immediately. Injection site bruising and soreness. This drug may cause thromboembolic episode causing tight chest sensation or difficulty breathing. Headache, irritability, fatigue, restlessness, edema, depression.

Contact the Physician Immediately

If you miss your scheduled dose, contact office immediately!
If the patient exhibits any signs or OHSS (abdominal cramps, bloating, abdominal discomfort) or if patient has any difficulty breathing as described above.

Missed Dose

It is crucial that this dose be given EXACTLY at the date and time instructed by your physician. If you miss your scheduled dose you must immediately contact your physician for instructions