Click below to find information and instructional videos on administering commonly used medications. While these videos are here for your reference, you should always listen to the specific instructions from your healthcare provider.

Learn more about proper hand washing, as well as handling and disposal of medications and medical waste on our Medication Safety page.

Stimulation Medications

Gonal-f ® Redi-Ject Pen (follitropin alfa injection)

Gonal-f ® RFF Multi-dose Vial(follitropin alfa injection)

Gonal-f ® 75IU Vial(follitropin alfa injection)

Follistim ® AQ (follitropin beta injection)

Menopur ® (menotropins for injection)

“Trigger” Injections

Novarel ® (chorionic gonadotropin for injection)

Ovidrel ® choriogonadotropin alpha for injection)

Pregnyl ® (chorionic gonadotropin for injection)

hCG (human chorionic gonadotropin)

GnRH Products

Leuprolide Acetate (“Lupron”) 2-Week Kit

Cetrotide ® (Cetrorelix Acetate for Injection) .25mg Kit

Ganirelix ® Injection 250mcg/0.5ml

Luteal Support/Progesterone

Crinone ® Vaginal Gel Applicators

Progesterone Vaginal Suppositories (Compounded)

Product Information and Instruction

Gonal-f RFF Redi-ject Pen™

Gonal-f RFF Multi-dose Vial 450IU and 1050IU™

Gonal-f RFF 75 IU Vial™

Product Information and Injection Instructions

Storage/Handling:
Gonal-f 450 IU Multi-Dose: Store at room temperature between 59°F and 77°F (15°C and 25°C). Once mixed, it must be used within 28 days. Protect from light.

Gonal-f RFF Pen 300 IU, 450 IU, and 900 IU: Store refrigerated at 36°F to 46°F (2°C to 8°C) until expiration date or at room temperature for up to one month. After initial use, store pen refrigerated or unrefrigerated for a maximum of 28 days.

Gonal-f RFF 75 IU vial: Store at room temperature between 59°F and 77°F (15°C and 25°C). Once mixed, it must be used immediately.

Common Side Effects/Comments:
Common side effects include abdominal pain, bloating, breast pain, nausea. This drug can also cause Ovarian Hyperstimulation syndrome (OHSS) which should be treated as a serious matter and doctor should be notified immediately. Injection site bruising and soreness. This drug may cause thromboembolic episode causing tight chest sensation or difficulty breathing.

Contact the Physician Immediately:
If the patient exhibits any signs or OHSS (abdominal cramps, bloating, abdominal discomfort) or if patient has any difficulty breathing as described above.

Missed Dose
If on the same day, you may usually inject dose as soon as you remember, however, contact your physician immediately for instructions. Do not double the dose on your own. Speak to your physician.

Follistim® (follitropin beta injection)

Storage/Handling: Store at room temperature between 59°F and 77°F (15°C and 25°C) for up to 90 days. If product is kept refrigerated then it is good until the expiration date written on the box. Once used store refrigerated or unrefrigerated for a maximum of 28 days.

Common Side Effects/Comments: Common side effects include abdominal pain, bloating, breast pain, nausea. This drug can also cause Ovarian Hyperstimulation syndrome (OHSS) which should be treated as a serious matter and doctor should be notified immediately. Injection site bruising and soreness. This drug may cause thromboembolic episode causing tight chest sensation or difficulty breathing.

Contact the Physician Immediately: If the patient exhibits any signs or OHSS (abdominal cramps, bloating, abdominal discomfort) or if patient has any difficulty breathing as described above.

Missed Dose If on the same day, you may usually inject dose as soon as you remember, however, contact your physician immediately for instructions. Do not double the dose on your own. Speak to your physician.

Menopur® (menotropins)

MENOPUR® (menotropins for injection) Injection Training Video

Storage/Handling:
Store at room temperature between 59°F and 77°F (15°C and 25°C) or refrigerated at a temperature of 36°F to 46°F (2°C to 8°C). Once it is mixed, it must be used Immediately

Contact the Physician Immediately:
If the patient exhibits any signs or OHSS (abdominal cramps, bloating, abdominal discomfort) or if patient has any difficulty breathing as described above.

Clomid (clomiphene citrate)

Information: Clomiphene citrate is an oral tablet utilized by physicians to help facilitate ovulation by increasing the release of GnRH (gonadotropin releasing hormone) by the hypothalmus. Dosing and physician instruction may vary, so it is important to listen to the directions from your doctor or nurse.

Storage/Handling:
Store at room temperature between 59°F and 86°F (15°C and 30°C).

Common Side Effects/Comments:
Side effects include hot flashes, abdominal discomfort, blurred vision, insomnia, nervousness, breast tenderness, ovarian cysts, ovarian hyperstimulation syndrome (OHSS) (excessive fluid retention and enlargement of ovaries usually with severe abdominal discomfort), ovarian enlargement

Contact the Physician Immediately:
If a patient experiences visual disturbances such as blurring, spots, or flashes. Or if patient experiences symptoms of ovarian hyperstimulation as described above.

Novarel 5,000IU (chorionic gonadotropin for injection)

NOTE THAT THE ONLY AVAILABLE PRESENTATION OF NOVAREL IS 5,000IU. IF YOU ARE INSTRUCTED TO INJECT 10,000IU, YOU MUST PERFORM THESE INSTRUCTIONS TWICE!

MIXING AND INJECTION INSTRUCTIONS: NOVAREL® (chorionic gonadotropin for injection, USP).

Storage/Handling:
Store at room temperature between 59°F and 77°F (15°C and 25°C.

Contact the Physician Immediately:
If you miss your scheduled dose, contact office immediately!
If the patient exhibits any signs or OHSS (abdominal cramps, bloating, abdominal discomfort) or if patient has any difficulty breathing as described above.

Missed Dose
It is crucial that this dose be given EXACTLY at the date and time instructed by your physician. If you miss your scheduled dose you must immediately contact your physician for instructions.

Ovidrel (choriogonadotropin alfa for injection)

Storage/Handling:
Store at room temperature between 59°F and 77°F (15°C and 25°C) for up to 30 days or refrigerate at a temperature of 36°F to 46°F (2°C to 8°C) until expiration date. Protect from light.

Common Side Effects/Comments:
Common side effects include local discomfort, bruising and soreness at the injection site; ovarian hyperstimulation syndrome (OHSS) (excessive fluid retention and severe abdominal discomfort), ovarian enlargement, headache, irritability, restlessness, depression, fatigue, edema, precocious puberty. There is potential for thromboembolic events (chest tightness). Ovarian enlargement, headache, irritability, restlessness, depression, fatigue, edema. ovaran cysts, abdominal pain, nausea, vomiting, breast pain, flatulence, abdominal enlargement, and itching.

Pregnyl (human chorionic gonadotropin for injection

Storage/Handling:
Store at room temperature between 59°F and 77°F (15°C and 25°C.

Leuprolide Trigger Injection

Mandell’s Clinical Pharmacy can custom compound Leuprolide trigger injections in a pre-filled syringe, with the exact dose requested by the physician. Since it comes in a pre-filled syringe, no mixing or drawing up of medication is required. Please do not confuse Leuprolide trigger with Leuprolide 2 Week Kit. While they are made of the same medication, their respective uses are substantially different. Please follow the specific instructions from your physician or nurse when administering this medication, as treatment approach can vary between IVF centers.

Common Side Effects/Comments:
Common side effects include local discomfort, bruising and soreness at the injection site; ovarian hyperstimulation syndrome (OHSS) (excessive fluid retention and severe abdominal discomfort), vaginal bleeding, pelvic pain, breast tenderness, hot flashes, vaginal dryness, constipation, headache, weakness, and dizziness. There is potential for serious pulmonary conditions and thromboembolic events (difficulty breathing or chest tightness).

Contact the Physician Immediately:
If the patient experiences an allergic reaction (difficulty breathing, closing of the throat, swelling of the lips, tongue or face, or hives); difficulty urinating, bone pain, numbness, tingling or weakness in the legs or arms. If the patient experiences symptoms of ovarian hyperstimulation syndrome (OHSS) (excessive fluid retention and severe abdominal discomfort) or symptoms of pulmonary conditions and thromboembolic events (difficulty breathing or chest tightness).

hCG (Human Chorionic Gonadotropin for injection)

Storage/Handling:
Store at room temperature between 59°F and 77°F (15°C and 25°C.

Leuprolide (Lupron) Two Week Kit

*The instructions above come from a video made by the original manufacturer of brand name Lupron. While the instructions are the same, the brand name “Lupron” product is no longer available. As a result, the Leuprolide Two Week Kit you receive may look slightly different than the item depicted in the video above. However, the medication is the same.

Storage/Handling:
Store in the original carton at room temperature between 59°F and 77°F (15°C and 25°C). Refrigerate after first use at a temperature of 36°F to 46°F (2°C to 8°C) after opening for up to 30 days. Protect from light.

Common Side Effects/Comments:
Common side effects include local discomfort, bruising and soreness at the injection site; ovarian hyperstimulation syndrome (OHSS) (excessive fluid retention and severe abdominal discomfort), vaginal bleeding, pelvic pain, breast tenderness, hot flashes, vaginal dryness, constipation, headache, weakness, and dizziness. There is potential for serious pulmonary conditions and thromboembolic events (difficulty breathing or chest tightness).

Cetrotide

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Storage/Handling:
Cetrotide 0.25 mg: Store refrigerated at a temperature of 36°F to 46°F (2°C to 8°C). Once it is mixed, it must be used immediately. Protect from light and moisture.

Cetrotide 3 mg: Store at room temperature between 59°F and 77°F (15°C and 25°C). Once it is mixed, it must be used immediately. Protect from light and moisture. immediately. Protect from light and moisture.

Contact the Physician Immediately:
If the patient experiences symptoms of ovarian hyperstimulation syndrome (OHSS) (excessive fluid retention and severe abdominal discomfort).

Ganirelix Acetate

Storage/Handling:
Store at room temperature between 59°F and 77°F (15°C and 25°C). Protect from light.

Common Side Effects/Comments:
Common side effects include local discomfort, bruising and soreness at the injection site; ovarian hyperstimulation syndrome (OHSS) (excessive fluid retention and severe abdominal discomfort), abdominal pain, headache, vaginal bleeding, and nausea. Packaging contains natural rubber latex which may cause allergic reaction.

Contact the Physician Immediately:
If the patient experiences symptoms of ovarian hyperstimulation syndrome (OHSS) (excessive fluid retention and severe abdominal discomfort).

Micro-dose Leuprolide

Information: Micro-dose Leuprolide is utilized by physicians in a similar manner to the Leuprolide 2-week Kit, but it is a variation with regards to dosing strength and timing of doses. it is very important to follow the specific instructions from your fertility center to ensure you are compliant with the protocol you have been prescribed.

Storage/Handling: Store in refrigerator (DO NOT FREEZE). Discard within 28 days of first use.

Common Side Effects/Comments:
Common side effects include local discomfort, bruising and soreness at the injection site; ovarian hyperstimulation syndrome (OHSS) (excessive fluid retention and severe abdominal discomfort), vaginal bleeding, pelvic pain, breast tenderness, hot flashes, vaginal dryness, constipation, headache, weakness, and dizziness. There is potential for serious pulmonary conditions and thromboembolic events (difficulty breathing or chest tightness).

Missed Dose
If you miss a dose, contact your physician.

Progesterone in Oil

Storage/Handling:
Store at room temperature between 59°F and 77°F (15°C and 25°C). Protect from light.

Common Side Effects/Comments:
Common side effects include local discomfort, bruising and soreness at the injection site; breakthrough bleeding, weight changes, changes in cervical secretions, breast tenderness, secretion of breast milk, acne, skin sensitivity reactions, hair loss, fever, insomnia, nausea, fluid retention.

Contact the Physician Immediately:
If the patient experiences breast tenderness or enlargement, numbness or pain in the arm or leg, pain in the chest or groin, severe headache, stomach pain, sudden shortness of breath, unusual weakness, vision or speech problems, or yellowing of the skin.

Endometrin (progesterone insert)

Instructions for Use – English

ENDOMETRIN® (progesterone) is a vaginal insert that contains the hormone progesterone, one of the hormones essential for helping you to become and to stay pregnant. ENDOMETRIN is for women who need extra progesterone while undergoing treatment in an Assisted Reproductive Technology (ART) program.
Important Safety Information
Do not use ENDOMETRIN if you:
Are allergic to anything in ENDOMETRIN
Have unusual vaginal bleeding that has not been evaluated by a doctor
Currently have or have had liver problems
Have or have had blood clots in the legs, lung, eyes, or elsewhere in your body
Progesterone can increase your chance of getting blood clots. Blood clots can be serious and lead to death. Serious blood clots include those in the legs, lungs, eyes, heart, and brain.
Call your doctor and get medical help right away if you have: persistent lower leg pain, sudden shortness of breath, coughing up blood, sudden blindness (partial or complete), severe chest pain, sudden severe headache, vomiting, dizziness, or fainting, weakness in an arm or leg, or trouble speaking, yellowing of the skin and/or white of the eyes indicating possible liver problems.
Common side effects seen with ART and ENDOMETRIN included pelvic pain after surgery, abdominal pain, nausea, and swollen ovaries (ovarian hyperstimulation syndrome).

Crinone (progesterone gel)

Instructions for Use Video – Click HERE

Instruction Sheet – Click HERE

Patient Instructions

Storage/Handling:
Store at room temperature between 59°F and 77°F (15°C and 25°C). Protect from light.

Common Side Effects/Comments:
Side effects include breakthrough bleeding, weight changes, acne, skin sensitivity reactions, hair loss, changes in cervical secretions, breast tenderness, secretion of breast milk, nausea, dizziness, fever, insomnia , fluid retention, and depression.

Contact the Physician Immediately:
If the patient experiences numbness or pain in the arm or leg, pain in the chest or groin, breast tenderness or enlargement, , severe headache, stomach pain, unusual weakness, vision or speech problems, yellowing of the skin, sudden shortness of breath,

All Sales Are Final

Please be informed that for consumer protection, all medication is non-returnable and non-refundable. This ensures that your medication has been maintained properly and has not been tampered with. Mandell’s will not accept any medication for returns or refunds under any circumstances. All sales are final. We do not take responsibility for unused medication for any reason. Federal Law Prohibits Return of Prescription Medication for Resale.